Thomas Werfel Selected Research

Histamine H4 Receptors

1/2020	The role of the histamine H4 receptor in atopic dermatitis and psoriasis.
1/2019	Efficacy and safety of the histamine H4 receptor antagonist ZPL-3893787 in patients with atopic dermatitis.
12/2016	Genetic variations within the promotor region of the human histamine H4 receptor gene in psoriasis patients.
8/2011	The histamine H4 receptor is highly expressed on plasmacytoid dendritic cells in psoriasis and histamine regulates their cytokine production and migration.
2/2011	The role of the histamine H4 receptor in atopic dermatitis.
1/2011	Pathogenetic and therapeutic implications of the histamine H4 receptor in inflammatory skin diseases and pruritus.
1/2009	Histamine H4 receptor antagonism reduces hapten-induced scratching behaviour but not inflammation.

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Thomas Werfel Research Topics

Disease

75	Atopic Dermatitis (Atopic Eczema) 09/2022 - 03/2002
39	Inflammation (Inflammations) 01/2022 - 03/2002
33	Hypersensitivity (Allergy) 10/2022 - 03/2002
22	Skin Diseases (Skin Disease) 09/2021 - 06/2005
18	Psoriasis (Pustulosis Palmaris et Plantaris) 09/2022 - 12/2003
16	Eczema 06/2022 - 01/2004
16	Infections 03/2022 - 02/2006
14	Food Hypersensitivity (Food Allergy) 01/2022 - 07/2008
11	Asthma (Bronchial Asthma) 01/2022 - 01/2009
10	Pruritus (Itching) 01/2021 - 01/2005
8	Allergic Contact Dermatitis 01/2022 - 01/2006
6	COVID-19 03/2022 - 01/2020
6	Contact Dermatitis (Eczema, Contact) 01/2022 - 05/2008
5	Atrophy 01/2021 - 01/2005
4	Chronic Urticaria 01/2022 - 01/2009
4	Urticaria (Hives) 01/2021 - 05/2008
4	Necrosis 01/2011 - 12/2003
3	Dermatitis 11/2021 - 01/2009
3	Anaphylaxis (Anaphylactic Shock) 01/2021 - 01/2021
3	Nasal Polyps (Nasal Polyp) 01/2021 - 01/2020
3	Rhinosinusitis 01/2021 - 01/2020
3	Neoplasms (Cancer) 01/2018 - 09/2009
3	Overweight 01/2014 - 09/2009
3	Superinfection 03/2013 - 11/2008
2	Seasonal Allergic Rhinitis (Hay Fever) 01/2020 - 07/2006
2	Herpes Simplex 01/2020 - 09/2009
2	Disease Progression 01/2018 - 03/2013
2	Cutaneous Lupus Erythematosus 01/2012 - 10/2008
2	Perioral Dermatitis 09/2009 - 07/2008
2	Erythema 12/2008 - 01/2005

Drug/Important Bio-Agent (IBA)

38	AllergensIBA 10/2022 - 10/2004
22	CytokinesIBA 01/2021 - 12/2003
19	Histamine (Histamine Dihydrochloride)FDA Link 10/2021 - 03/2002
16	Immunoglobulin E (IgE)IBA 01/2022 - 10/2004
12	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2022 - 01/2005
12	Biological ProductsIBA 01/2022 - 04/2006
9	dupilumabIBA 06/2022 - 07/2016
9	pimecrolimus (Elidel)FDA Link 01/2021 - 01/2004
7	Histamine H4 ReceptorsIBA 01/2020 - 01/2009
7	Calcineurin InhibitorsIBA 01/2020 - 01/2005
7	Proteins (Proteins, Gene)FDA Link 01/2020 - 10/2006
6	AntigensIBA 09/2022 - 01/2009
6	Interleukin-13IBA 04/2021 - 05/2006
5	Interleukin-12 (IL 12)IBA 06/2012 - 10/2004
4	Air Pollutants (Pollutants, Air)IBA 01/2022 - 09/2009
4	ChemokinesIBA 10/2021 - 12/2010
4	Cyclosporine (Ciclosporin)FDA LinkGeneric 04/2021 - 04/2006
4	Histamine Receptors (Histamine Receptor)IBA 01/2020 - 01/2011
4	Messenger RNA (mRNA)IBA 01/2017 - 03/2009
4	Interleukin-27 (Interleukin 27)IBA 07/2012 - 07/2009
4	Interleukin-18 (Interleukin 18)IBA 01/2012 - 12/2003
3	Irritants (Vesicants)IBA 01/2022 - 05/2008
3	Monoclonal AntibodiesIBA 01/2022 - 07/2016
3	DNA (Deoxyribonucleic Acid)IBA 10/2021 - 12/2016
3	Antimicrobial PeptidesIBA 10/2021 - 10/2013
3	VaccinesIBA 01/2021 - 11/2012
3	Interleukin-4 (Interleukin 4)IBA 01/2020 - 04/2016
3	Pharmaceutical PreparationsIBA 01/2020 - 09/2009
3	Interleukin-22 (IL-22)IBA 01/2020 - 12/2010
3	Ribonuclease 7IBA 01/2020 - 01/2018
3	InterleukinsIBA 10/2018 - 06/2005
3	Small Interfering RNA (siRNA)IBA 01/2018 - 06/2013
3	ExotoxinsIBA 01/2014 - 02/2007
3	Immunoglobulin G (IgG)IBA 07/2011 - 11/2006
3	Interferon-gamma (Interferon, gamma)IBA 12/2008 - 12/2003
3	Azathioprine (Imuran)FDA LinkGeneric 12/2007 - 10/2006
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 06/2005 - 12/2003
2	Omalizumab (Xolair)FDA Link 01/2022 - 01/2021
2	EnzymesIBA 01/2022 - 06/2013
2	Fibronectins (Fibronectin)IBA 01/2022 - 07/2011
2	Carrier Proteins (Binding Protein)IBA 01/2022 - 07/2011
2	Antiviral Agents (Antivirals)IBA 10/2021 - 01/2018
2	GlucocorticoidsIBA 04/2021 - 07/2014
2	Janus Kinase InhibitorsIBA 01/2021 - 01/2021
2	4'-N,N-dimethylamino-4-aminoazobenzeneIBA 01/2021 - 01/2015
2	Janus KinasesIBA 01/2021 - 01/2020
2	AntibodiesIBA 01/2020 - 02/2007
2	Interleukin-33IBA 01/2020 - 02/2013
2	Filaggrin ProteinsIBA 01/2020 - 01/2017
2	Immunoglobulin A (IgA)IBA 01/2019 - 01/2004
2	Interleukin-13 Receptors (Interleukin 13 Receptor)IBA 10/2018 - 07/2016
2	Catalytic DNA (Deoxyribozyme)IBA 02/2016 - 07/2012
2	Tryptases (Tryptase)IBA 05/2015 - 10/2006
2	N- palmitoyl- S- (2,3- bis(palmitoyloxy)propyl)cysteinyl- seryl- lysyl- lysyl- lysyl- lysineIBA 05/2015 - 10/2010
2	ThioredoxinsIBA 05/2015 - 07/2011
2	1- ((5- chloro- 1H- indol- 2- yl)carbonyl)- 4- methylpiperazineIBA 12/2013 - 01/2009
2	Dinitrochlorobenzene (DNCB)IBA 09/2011 - 01/2009
2	HaptensIBA 09/2011 - 01/2009
2	Interleukin-17 (Interleukin 17)IBA 04/2011 - 12/2010
2	LipopolysaccharidesIBA 01/2011 - 12/2003
2	InterferonsIBA 01/2011 - 06/2005
2	Toll-Like Receptor 2IBA 04/2008 - 03/2004
2	AutoantibodiesIBA 12/2007 - 11/2006
2	Mycophenolic Acid (Cellcept)FDA LinkGeneric 12/2007 - 11/2006
2	Methylprednisolone FDA LinkGeneric 12/2007 - 11/2006
2	FumaratesIBA 04/2006 - 01/2002

Therapy/Procedure

35	Therapeutics 06/2022 - 01/2005
11	Immunotherapy 01/2022 - 12/2006
3	Phototherapy (Light Therapy) 10/2006 - 01/2004
2	Cesarean Section (Caesarean Section) 01/2022 - 01/2014